Thanks for the input. FWIW, I have used various development boards with FTDI chips over the years. I am sure I have installed drivers.
I did install Waveforms 3.9.1 and the dwf.framework. Not the DigilentFtdiDriver.pkg. I have not tried to access the device through any other application - with the exception of the MacOS System Report to review USB devices.
Here is the output from the digi_enum.py script :
dyld: warning, LC_RPATH @executable_path/../Frameworks in /Library/Frameworks/dwf.framework/dwf being ignored in restricted program because of @executable_path
Digilent FTDI Enumeration library loaded
Devices: 1
1. SN:210321AA28F7 'Digilent USB Device' flags: 0x0 type: 0x8 id: 0x4036014 locid: 0x141b0
FTDI Version: 0x10202
Devices: 1
1. SN: '' flags: 0x1 type: 0x3 id: 0x0 locid: 0x0
DMGR Version: 2.8.4
Devices: 0
DWF Version: 3.9.1
Devices: 0
Run as user or sudo - same result. I am not sure why, but with the powered USB hub the device is not seen by the OS (or the script). Those USB ports are otherwise functional.
Thanks,
Doug