Hello there, Board: ZYBO IDE: Vivado 2015.3 Design Edition OS: Windows 10 X64 Host ID: Gazi-Laptop The Hardware Manager detected the PS and PL once but then the OS crashed and I had to reboot. After that, I get this error message trying to connect to the device: ERROR: [Labtoolstcl 44-26] No hardware targets exist on the server [localhost] Check to make sure the cable targets connected to this machine are properly connected and powered up, then use the disconnect_hw_server and connect_hw_server commands to re-register the hardware targets. I ran the hw_server manually as administrator, ran Vivado 2015.3 IDE as administrator and went to the Hardware manager. In TCL window, I type: connect_hw_server -url Gazi-Laptop:3121 and hit enter and I get the same message. I have tried two different USB cables (one from Digilent) and Different USB ports. I have even uninstalled and reinstalled Vivado 2015.3 Design Edition along with Cable Drivers. I have tried manually reinstalling the cable drivers as mentioned on Xilinx. However, I cannot communicate with the device except for that one time after which my system crashed. JP5 is set to JTAG. Any help is appreciated.